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    <b>Does tacrolimus increase blood sugar?</b> Cyclosporin and tacrolimus cause post-transplant diabetes mellitus by a number of mechanisms, including decreased insulin secretion, increased insulin resistance or a direct toxic effect on the beta cell. However, their use should be balanced against the increased incidence of transplant rejections.
    <b>Is tacrolimus covered by Medicare?</b> Affected patients are those who rely on Medicare Part D coverage for their immunosuppressant drugs and: No immunosuppressant drug is FDA-approved for lung transplant and only tacrolimus and cyclosporine are listed in the CMS-approved compendia as appropriate for off-label use in lung transplant.
    <b>Is tacrolimus nephrotoxic?</b> The molecular basis of cyclosporine and tacrolimus nephrotoxicity is less well understood, but there is evidence that it may be mediated by the calcineurin pathway as well. Thus, cyclosporine and tacrolimus binding proteins are present at a high concentration in the kidney (higher than in the liver and spleen).
    <b>Does Medicare pay for Ozempic?</b> Ozempic is not covered by your prescription insurance plan at this time. However, your health care provider may request coverage for Ozempic by submitting a formulary exception.
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